32 Gebelik Haftasından Küçük Prematüre Bebeklerde Patent Duktus Arteriyozus Trombosit Sayısı ve Ortalama Trombosit Hacminden Etkilenmemektedir

Abstract

Objective: There have been controversial data regarding the effect of platelet count and functions on spontaneous and medical closure of patent ductus arteriosus (PDA) in preterm infants. Our aim was to investigate the relationship between platelet count and mean platelet volume (MPV) and the medical and spontaneous closure of PDA in premature infants of <32 weeks of gestational age. Material and Methods: Patients were cathegorized as (1) those with a hemodynamically significant PDA (HSPDA) at 12 to 24 hours of age and (2) those in whom PDA was small or closed spontaneously. Patients with a HSPDA were further divided into two subcathegories: Patients achieved ductal closure with medical treatment and those needed surgical closure. Results: Seventy-five patients were included into the study population: 46 patients had a HSPDA, while in 29 ductus arteriosus closed spontaneously by the first 24th hour of life. Platelet count and MPV were similar between patients with and without a HSPDA (p>0.05). Of the 46 patients with a HSPDA, 38 achieved a successful PDA closure after medical treatment, while 8 needed surgical ligation. Again, there was no significant difference regarding platelet count and MPV between patients responded to medical therapy and those did not. Conclusion: Although platelet count and MPV may play a role in physiologic mechanisms of ductal closure; there has been insufficient and controversial clinical data regarding the effect of platelet count and functions on the fate of PDA in preterm infants. Prospective studies in this regard are warranted.