Abstract
Our understanding of the quality and duration of immunity to COVID-19 following natural infection remains important area of public health research. The long-term kinetics of IgG antibodies to the spike and nucleocapsid (N) proteins of the SARS-CoV-2 virus are of particular interest as easily measurable potential indirect markers of both previous infection and resistance to reinfection. Previous studies in hospitalized patients have found that anti-N IgG levels decline over time. We undertook this study to characterize the kinetics of anti-N IgG in a longitudinal cohort of health care workers in an acute hospital setting.
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