Abstract
By monitoring in real time metabolic intermediates and reaction fluxes in intact tissues, localized magnetic resonance spectroscopy (MRS) opens new perspectives for the early detection of tumor response to therapy [6]. 31P MR spectra of neoplastic tissues do not generally exhibit tumor-specific resonances. However, in comparison with healthy tissues, significant alterations can be detected in peak areas of metabolites involved in cell bioenergetics (nucleoside triphosphates, phosphocreatine, inorganic phosphate) or in phospholipid biosynthesis and turnover. In particular, 31P MR spectra of experimental and clinical tumors generally exhibit elevated phosphomonoester (PME) and phosphodiester (PDE) signals, primarily arising from phospholipid precursors and/or catabolites [such as phosphorylcholine (PCho), phosphorylethanolamine (PEtn), glycerophosphorylcholine (GroPCho), glycerophosphorylethanolamine (GroPEtn) and sn-glycerol 3-phosphate (GroP)]. PME and PDE peak areas generally exhibit large variability in different tumors and may undergo significant alterations during tumor growth or in response to therapy.
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