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Abstract
Hair follicles (HFs) of mammalian epidermis are cycling throughout lifetime in order to continuously generate new hairs. Stem cells (SCs) residing in the bulge and hair germ fuel this cycle of hair regeneration that comprises three phases: (a) growth (anagen), where bulge and hair germ cells proliferate to generate the new hair shaft; (b) HF regression (catagen), where the HF keratinocytes undergo apoptosis and surviving cells move upwards to regenerate the hair germ and inner bulge; (c) resting (telogen), characterized by stem cell quiescence.
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