318 The long non-coding RNA LINC00958 is overexpressed in psoriasis epidermis and induces keratinocyte proliferation

Abstract

Psoriasis is a common, chronically relapsing inflammatory skin disease characterized by epidermal hyperproliferation. LncRNAs are >200 nucleotide long transcripts, which do not code for protein but possess diverse regulatory functions. To date, little is known about the contribution of lncRNAs to psoriasis. Here, we identified lncRNAs with altered expression using transcriptomic profiling on epidermal cells sorted from psoriasis and healthy skin. LINC00958 was identified as a lncRNA overexpressed in keratinocytes from psoriasis skin lesions, and confirmed by RT-qPCR and single molecule in situ hybridization.