318 Short-term exposure to Western diet (WD) predisposes mice to psoriasis-like skin and joint inflammation

Abstract

We have previously shown that long-term feeding (>3 month) with a high sugar, moderate fat diet (i.e., Western diet, WD) enhances susceptibility of mice to imiquimod-induced psoriasiform dermatitis (PsD), suggesting that specific components of diet increase susceptibility to PsD. Herein, we determined that short-term feeding (<1 month) with WD alone was sufficient to induce clinically and molecularly-detectable PsD. After weaning, C57BL/6 mice were fed a WD or an otherwise nutritionally matched, control diet (CD) for 1 month.