Abstract
Neuronal proteins have been traditionally viewed as being derived solely from the soma, wherein the preponderance of ribosomal/translational machinery resides. However, accumulating evidence indicates that non-somal sites, such as the dendrite and axon, are capable of a more autonomous role in terms of new protein synthesis. While this mechanism allows for more rapid, on-demand regulation of neuronal structure and function, it remains unclear precisely how the requisite RNA is trafficked into the axon for this purpose.
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