Abstract
Early life stress is a risk factor for chronic pain in adulthood, yet little is known about the underlying mechanisms. The purpose of this experiment was to evaluate whether healthy individuals reporting high levels of early life stress would show enhanced spontaneous pain and neurogenic flare responses to topical capsaicin. Capsaicin temporarily induces localized spontaneous pain and neurogenic inflammation by engaging mechanisms involved in neuropathic and inflammatory pain. A total of 2,625 participants were prescreened for their early life stressful events using the Early Trauma Inventory Self-report-short form (ETISR-SF).
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