Abstract
Adhesion of leukocytes, platelets, and/or red blood cells to the endothelium is characteristic of and contributes to pathology in a variety of conditions including sickle cell disease, sepsis, cardiovascular diseases, and peripheral vascular diseases. Nitric Oxide (NO) is known to reduce blood cell adhesion to the endothelium. Growing evidence has shown that nitrite is reduced to NO, preferentially under hypoxic conditions. We have explored the effects of nitrite on blood cell adhesion in vitro and using intra vital microscopy. Using a flow micro channel tissue culture slides, confluent HUVEC cells activated by interleukin-1β (IL-1β), we observed that 50 μM nitrite reduced red blood cell adhesion under shear stress by 72% (n = 3, p
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