314 Porokeratosis of Mibelli in the Tunisian Population

Abstract

Porokeratosis (PK) is a rare group of acquired or hereditary genodermatosis characterized by an epidermal differentiation disorder and sharing common histology. Their etiopathogenesis is still not fully understood. Porokeratosis of Mibelli (PM) is a rare autosomal form of PK, linked to the MVK and PMVK genes. We aim to establish molecular evidence of PM in our Tunisian patients. 9 PK patients belonging to a cohort of 2 families from central Tunisia were sequenced for PMVK and MVK genes by the Sanger technique.