Abstract
In the most recent version of the EAU Guidelines on Male Hypogonadism, the contraindication severe LUTS due to BPH has been removed. In an ongoing registry study we monitored urinary function for a maximum of 12 years. We report data from 823 men with symptomatic hypogonadism participating in a registry study started in 2004. 428 men received testosterone undecanoate (TU) injections 1000 mg/12 weeks following an initial 6-week interval (T-group), 395 opted against TTh serving as controls (CTRL). Changes over time between groups were compared by a mixed effects model for repeated measures with a random effect for intercept and fixed effects for time, group and their interaction and adjusted for age, weight, waist circumference, blood pressure, fasting glucose, lipids and quality of life to account for baseline differences between groups. Mean (median) follow-up: T-group 8±3 (9), CTRL 9±2 (10) years. Total observation time: T-group 3594, CTRL 3522 years. Baseline age: 58±7 (T-group) vs. 64±5 years (CTRL).
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