Abstract
CD133 and CD117 as determined by FACS analysis. The expression of VEGF, TGF-alpha, FGF-2, endothelial nitric oxide synthase and angiopoietin-2 in expanded CD34 cells increased compared with freshly isolated CD34 cells. Expanded CD34 cell transplantation had dose-dependently reduced liver fibrosis, with the decrease of collagen type-I and alpha-SMA positive cells after six weeks of CCl4 treatment. In high dose of expanded CD34 cell transplanted livers, the number of PCNA positive hepatocyte increased significantly at six weeks after CCl4 treatment. The expression of TIMP-1 was significantly decreased in high dose of expanded CD34 cell transplanted livers. Conclusion: Our data suggest that expanded CD34 cells may represent a promising strategy for a successful cell therapy.
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