Abstract
Hidradenitis Suppurativa (HS) is a chronic inflammatory skin disease clinically characterized by recurrent painful deep-seated nodules and abscesses commonly found in the apocrine-bearing localization of the body. This cumbersome disorder has a heritability estimated at 80%. While more than one-third of patients has a family history of HS, less than 7% of them showed mutations in one of the three genes encoding the gamma-secretase subunits that have been associated with autosomal dominant forms of the disease.
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