Abstract
Melanin is synthesized in the human epidermis within melanocytes and transferred to keratinocytes to regulate skin colour, where it provides protection against ultraviolet radiation (UVR)-induced damage. The Fitzpatrick scale stratifies our skin’s tanning response to UVR into six skin phototypes (SPT), SPT-I lightest to SPT-VI darkest. This study investigated the impact of UVR and visible light stimulation on Caucasian skin ex vivo. We treated skin obtained from SPT-I, -II and -III healthy donors with one daily doses of 6 J/cm2 (UVR) and 140 J/cm2 (blue or green light) for a period of three days, and assessed their influence on observable surface tanning response, histological melanin content, DNA damage, and cell apoptosis.
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