Abstract
Background and Aims: Viral load dynamics of infectious diseases among diverse group are the most important aspects of epidemiological studies to control the disease for the destination countries. Objectives: To the best of viral dynamics, the present study was conducted to determine the virus DNA level, and the frequency of infection among the age group (1–15, 16–30, 31–45, 46–60, 61–75 years) and genders in Indian population. Methods: A total of 515 suspected cases including 378 (73.39%) male and 137 (26.60%) female, with ages ranging between 06 and 75 years (mean ± standard deviation: 35.90 ± 14.14 years) participated in this study From those, blood sample were collected and viral DNAs were extracted from the plasma and analyzed by Real-time PCR system with the combination of artus® HBV RG PCR assay for the specific region of HBV genome. Results: HBV DNA was detected in a total of 360/515 (69.90%) plasma samples; 269 (74.72%) male and 91 (25.27%) female. The level for viral load of HBV DNA ranged from 10.5 to >2 × 107 IU/ml in the plasma samples (median 461 IU/ml). On the evaluation of demographic data for the age groups and genders, the comparison of viral loads between the age groups and genders indicated no significant correlation (P > 0.05). However, the plasma HBV DNA infection rate among female significantly decreased in the age group of 16–30 years (P = 0.04). There was no significant difference of viral load between the genders in the study population (P > 0.05). Conclusions: Considering the results of the HBV DNA viral load and evaluation of studied group outcome can help to implement the diagnosis and prevention procedures in such cases, as well as to emphasize the risk of HBV transmission in the group of population. The authors have none to declare.
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