Abstract
Today, it is possible to identify the majority of the newborns with a high risk of atopy by recording family history (FH) and determination of cord-blood IgE (CB-IgE). But this selective screening cannot detect the total number of newborns at risk of atopy. The aim of the present study was to investigate the value of T-cell suppressor count in newborns for the prediction of atopy. We studied CB-IgE, T-cell counts and FH in 138 non-selected newborns. No measures were undertaken for the prevention of atopy. A control determination of IgE and T-cell function was performed at 14 months age. All children with elevated CH-IgE and low T-Suppressor cell count in the cord blood (11%) developed clinical signs of atopy. The risk of atopy was significantly higher in children with low CB-T-suppressor cell count and pos. FH compared to normal controls (p 0,01). High CB-IgE or low T-suppressor cell count are of similar value for the prediction of atopy. At the age of 14 months, no correlation could be drawn between IgE, T-suppressor cell count and atopy symptoms.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
