Abstract
Objectives To study placental bed (PB) and microRNA expression in women with PE and PE, complicated by IUGR. Methods 200 women 18–43 yrs old were divided into 3 groups: I–50 with early onset PE: Ia with IUGR (34), IIb without IUGR (16); II–50 with late PE: IIa with IUGR (11); IIb without IUGR (39) and 100 – as control. Samples of PB were obtained during CS after prior patient’s informed consent. Results 44% primigravida in group_Ia and 18,1% in group_IIa conceived within 6 months after marriage. BMI was higher and cardiovascular disorders occurred more often in group_IIa than in group_Ia (p Conclusion A key role of placental site and mechanisms of placentation in early onset PE especially in combination with IUGR was suggested. Further research will help to create a basis for prediction, early diagnosis, and adequate management of those great obstetrical syndromes.
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