(308) Oxytocin Troches as an Adjunctive Intervention to Conventional Testosterone and Erectile Dysfunction Medication for Men with Sexuality Concerns

Abstract

Abstract Introduction Oxytocin (OT), a peptide hormone, is known to be involved in social interaction and the pleasure we derive from it is produced from the posterior pituitary. This neurotransmitter has a potential role in love, female reproductive functions, and social bonding. OT is released by both males and females, during skin to skin contact sexual arousal and orgasm/ejaculation (1,2). OT effects on the brain are dependent on its interactions with sex homes such as estrogen, progesterone, testosterone, and corticosterone. Oxytocin levels are implicated in male sexual responsivity. Oxytocin biological effects may include decrease social anxiety, increased pair bonding, intimacy and closeness enhance sexual receptivity, enhance perineal contractility, enhances pair bonding, nurturing, trust “cuddle hormone, increased intensity of orgasm in men and women, decreased latency to orgasmic release, increased pleasurable sensations and increased sexual desire and lubrication. Oxytocin troches have been used as an off label investigational compounded oxytocin as an adjunctive therapy for men’s sexual health. Objective We report the preliminary responder analysis results of a random retrospective survey on users of this medication. Methods A random convenience sample of 26 men from 5 centers ( Hawaii, Washington, Portland, Salt Lake City and Tulsa) who tried compounded oxytocin were surveyed. Surveys were anonymous, and participation was voluntary and uncompensated. Doses of Sublingual oxytocin were to be titrate up from 25 international units (IU) for optimization, but not to exceed 100 IU) Results Fourteen out of 26 participants (56%) were considered responders. Mean age was 43 and range was 22-77. Eighty-six of the participants had used between 50 IU and 100 IU and 50% were on TRT replacement whereas 57% were on Erectile medications. Only 21% were on both ED medications and TRT replacement. 86% of responders reported enhanced intimacy and connection with their partners, 100% would recommend the product to their friends. 93% of users planned to continue the medication. 86% noted increased overall pleasure and sexual satisfaction. 86% reported improved overall quality of their orgasm. There were no adverse events reported. Responders reported positive feedback which included: longer lasting before orgasmic release, increased nipple sensation, improved control with premature ejaculation, improved feelings during climax and increased ejaculate volume. Conclusions Oxytocin compounded troches appear to be a helpful addition to a preexisting treatment paradigm for erectile difficulty or testosterone replacement. This is a preliminary report with small numbers, and further larger randomized clinical trials are warranted and planned. Disclosure No