307 PARTIN TABLES′OVERALL ACCURACY TO PREDICT FINAL PATHOLOGICAL STAGE DETERIORATES IN PATIENTS WITH PROSTATE CANCERS DETECTED BY SATURATION RE-BIOPSY

Abstract

You have accessJournal of UrologyProstate Cancer: Staging1 Apr 2011307 PARTIN TABLES′OVERALL ACCURACY TO PREDICT FINAL PATHOLOGICAL STAGE DETERIORATES IN PATIENTS WITH PROSTATE CANCERS DETECTED BY SATURATION RE-BIOPSY Herbert Augustin, Marco Auprich, Günter Gallé, Falko Lainer, Badereddin Mohamad Al-Ali, and Karl Pummer Herbert AugustinHerbert Augustin Graz, Austria More articles by this author , Marco AuprichMarco Auprich Graz, Austria More articles by this author , Günter GalléGünter Gallé Graz, Austria More articles by this author , Falko LainerFalko Lainer Graz, Austria More articles by this author , Badereddin Mohamad Al-AliBadereddin Mohamad Al-Ali Graz, Austria More articles by this author , and Karl PummerKarl Pummer Graz, Austria More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.400AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The Partin Tables represent a widely used tool to predict pathologic stage in men with localized prostate cancer (PCa). Overall accuracy of the Tables was tested across different populations. However, potential limitations resulting from differences between PCa detected by an initial standard biopsy and saturation re-biopsy has not been analysed so far. METHODS Preoperative serum PSA, clinical stage, and biopsy Gleason sum from 445 patients treated with radical retropubic prostatectomy defined the 2007 Partin probabilities of organ confinement (OC), seminal vesicle invasion (SVI) and extracapsular extension (ECE). PCa was detected by initial biopsy with a maximum of 12 cores in 354 patients (79.5%) and by re-biopsy according a saturation scheme with 24 cores in 91 patients (20.5%). Receiver operating charateristic (ROC) area under the curve (AUC) assessed the predictive accuracy of 2007 Partin Tables relative to observed OC, ECE, and SVI. RESULTS The initial biopsy group presented with clinical stage T1c in 68.4% compared to the saturation group with 75.8% (p=0.369). The mean PSA level was 7.67ng/ml (¡À7.19) in the initial biopsy group, and 10.17ng/ml (¡À7.58) in the saturation group (p=0.004). The initial biopsy group showed Gleason Score ¡(6 in 73.2%, 7 in 20.6% and ¡°Ý8 in 6.2%, the saturation group in 70.3%, 18.7% and 11.0% (p=0.285), respectively. Histopathological evaluation of the prostatectomy specimens revealed stage pT2 in 75.7% of the initial biopsy group vs. 84.6% of the saturation re-biopsy group, pT3a in 16.7% vs. 9.9%, and pT3b in 7.6% vs. 5.5% (p=0.185), respectively. The Partin Tables AUC of the initial and the saturation biopsy group were 0.734 and 0.610 for OC, 0.634 and 0.543 for ECE, and 0.803 and 0.706 for SVI, respectively. CONCLUSIONS The overall accuracy of the 2007 Partin Tables to predict final pathological stage was clearly inferior in patients with prostate cancers detected by re-biopsy according a saturation scheme. Hereby, the accuracies might be undermined by higher mean PSA levels in the presence of similar pathological stages. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e125 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Herbert Augustin Graz, Austria More articles by this author Marco Auprich Graz, Austria More articles by this author Günter Gallé Graz, Austria More articles by this author Falko Lainer Graz, Austria More articles by this author Badereddin Mohamad Al-Ali Graz, Austria More articles by this author Karl Pummer Graz, Austria More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...