(307) Is Vitamin D Deficiency Associated with Low Testosterone Levels in Asian LUTS Patients?

Abstract

Abstract Introduction It has been hypothesized that vitamin D and testosterone levels are associated, but the evidence is still unclear. Objective We aimed to investigate the association between hypogonadism and vitamin D deficiency. Methods A retrospective analysis was performed on 471 Asian male who visited for the first time with LUTS (mean age 60.56±10.79 year) of two medical centers between 2014 and 2018. Serum vitamin 25(OH)D and testosterone levels in morning samples were measured. 25(OH) D was also classified as sufficiency (>30ng/mL), insufficiency (30-20ng/mL), deficiency (<20ng/mL), and testosterone as hypogonadism (<300ng/dL) and non-hypogonadism (≥300ng/dL). The association between 25(OH) D and total testosterone (T), free testosterone (FT), bioavailable testosterone (BT), and international index of erectile function (IIEF)-5 was analyzed using t-test, partial correlation analysis, and propensity matching (propensity score 1:2). The seasonal variation of 25(OH) D and testosterone were also analyzed by one-way ANOVA. Results Mean testosterone level and ages of hypogonadism (n=88) were 2.3±0.6ng/dL and 60.0±10.8 year, and those of non-hypogonadism (n=383) were 5.3±1.8ng/dL and 63.0±10.3 year. The mean value of 25(OH)D (20.6±11.4ng/mL vs. 20.1±8.5ng/mL, p=0.649) and number of 25(OH)D classification (sufficiency=13 [14.8%], insufficiency=24 [27.3%], deficiency=51 [58.0%] vs. sufficiency=52 [13.6%], insufficiency=124 [32.4%], deficiency=207 [54.3%], p=0.648) did not differ between hypogonadism and non-hypogonadism groups. There was no significant difference of 25(OH)D even after propensity matching for the ages, BMI, diabetes, coronary heart disease, cerebrovascular disease of the two testosterone groups (p=0.811). 25(OH)D also showed no association with the level of T, FT, BT or IIEF-5 total scores even after adjusting for age by partial correlation analysis (p=0.470, p=0.375, p=0.735 and p=0.461, respectively). In one-way ANOVA analysis, 25(OH)D was significantly higher in summer than winter (26.8±12.5ng/mL vs. 19.0±8.6ng/mL, p=0.02), whereas testosterone showed no seasonal variation. Conclusions We could not find a significant association between vitamin D deficiency and hypogonadism in elderly Asian LUTS patients, even after adjusting for age, BMI, diabetes, coronary heart disease, cerebrovascular disease. The association of vitamin D levels on sexual function and seasonal variation of testosterone remains still unclear. Further large and well-designed studies are needed to determine the association between vitamin D and testosterone levels in healthy individuals. Disclosure No