306 VALIDATION OF D'AMICO, SEATTLE, AND NCCN RISK STRATIFICATIONS FOR PROSTATE CANCER IN JAPANESE POPULATION

Abstract

You have accessJournal of UrologyProstate Cancer: Staging1 Apr 2011306 VALIDATION OF D'AMICO, SEATTLE, AND NCCN RISK STRATIFICATIONS FOR PROSTATE CANCER IN JAPANESE POPULATION Takuya Koie, Noriko Tokui, Teppei Okamoto, Kengo Imanishi, Yuichiro Suzuki, Naoki Sugiyama, Tohru Yoneyama, Shingo Hatakeyama, Shigemasa Kudoh, Kazuyuki Mori, Takahiro Yoneyama, Noritaka Kamimura, and Chikara Ohyama Takuya KoieTakuya Koie Hirosaki, Japan More articles by this author , Noriko TokuiNoriko Tokui Hirosaki, Japan More articles by this author , Teppei OkamotoTeppei Okamoto Hirosaki, Japan More articles by this author , Kengo ImanishiKengo Imanishi Hirosaki, Japan More articles by this author , Yuichiro SuzukiYuichiro Suzuki Hirosaki, Japan More articles by this author , Naoki SugiyamaNaoki Sugiyama Hirosaki, Japan More articles by this author , Tohru YoneyamaTohru Yoneyama Hirosaki, Japan More articles by this author , Shingo HatakeyamaShingo Hatakeyama Hirosaki, Japan More articles by this author , Shigemasa KudohShigemasa Kudoh Hirosaki, Japan More articles by this author , Kazuyuki MoriKazuyuki Mori Hirosaki, Japan More articles by this author , Takahiro YoneyamaTakahiro Yoneyama Hirosaki, Japan More articles by this author , Noritaka KamimuraNoritaka Kamimura Hirosaki, Japan More articles by this author , and Chikara OhyamaChikara Ohyama Hirosaki, Japan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.399AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The incidence of prostate cancer (Pca) is rapidly increasing in Asian population. A validated risk stratification for Asian people is necessary for appropriate treatment selection. AUA guideline recommends D'Amico's risk stratification for Pca. Other than D'Amico's risk stratification, Seattle group and National Comprehensive Cancer Network (NCCN) also postulate their own risk stratification. We examined whether these risk stratifications are applicable in Japanese population. METHODS From September 1993 to March 2010, 541 patients underwent radical prostatectomy for clinical stage T1c-T3 prostate cancer at our institution. The present study enrolled 370 patients who did not received neoadjuvant or adjuvant therapy. Biochemical recurrence-free survival (BRFS) rates were estimated using the Kaplan–Meier method, and the BRFS rates in the D'Amico, Seattle, and NCCN risk groups were compared using the log-rank statistic. RESULTS The mean age of the enrolled patients was 67.1 years, the median initial prostate-specific antigen (PSA) level was 7.61ng/ml, and the mean follow-up period was 44.4 months. According to D'Amico's risk stratification, 35, 280, and 60 patients were grouped into low-, intermediate-, and high-risk groups, respectively. On the basis of the Seattle risk stratification, 35, 282, and 53 patients were grouped into low-, intermediate-, and high-risk groups, respectively. According to the NCCN risk stratification, 30, 271, and 69 patients were grouped in low-, intermediate-, and high-risk groups, respectively. The BRFS rates at 44.4 months in the D'Amico low-, intermediate-, and high-risk groups were 83.1%, 79.6%, and 46.8%, respectively (P < 0.0001 at low and intermediate risk vs. high risk). The BRFS rates in the Seattle low-, intermediate-, and high-riskgroups were 79.8%, 79.8%, and 46.8%, respectively (P < 0.0001 at low and intermediate risk vs. high risk). The BRFS rates in the NCCN low-, intermediate-, and high-risk groups were 79.8%, 82.6%, and 46.8%, respectively (P < 0.0001 at low and intermediate risk vs. high risk). There was no statistically significant difference in BRFS between low-and intermediate-group in any risk stratifications. CONCLUSIONS The present risk stratification systems applied for biochemical recurrence after surgery could not discriminate Low- and Int-risk group in Japanese population. A new risk stratification is necessary for Asian population. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e124-e125 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Takuya Koie Hirosaki, Japan More articles by this author Noriko Tokui Hirosaki, Japan More articles by this author Teppei Okamoto Hirosaki, Japan More articles by this author Kengo Imanishi Hirosaki, Japan More articles by this author Yuichiro Suzuki Hirosaki, Japan More articles by this author Naoki Sugiyama Hirosaki, Japan More articles by this author Tohru Yoneyama Hirosaki, Japan More articles by this author Shingo Hatakeyama Hirosaki, Japan More articles by this author Shigemasa Kudoh Hirosaki, Japan More articles by this author Kazuyuki Mori Hirosaki, Japan More articles by this author Takahiro Yoneyama Hirosaki, Japan More articles by this author Noritaka Kamimura Hirosaki, Japan More articles by this author Chikara Ohyama Hirosaki, Japan More articles by this author Expand All Advertisement Advertisement PDF DownloadLoading ...