Abstract
The most common complication of herpes zoster (HZ) is post-herpetic neuralgia (PHN). There is an overall loss of sensory function and signs of denervation in the painful skin in most, but not all, patients with PHN. Application of topical capsaicin worsens PHN pain and allodynia in most subjects, suggesting that cutaneous afferents are still present and that the peripheral afferents and/or their central connections are chronically sensitized. This suggests that a mere reduction in overall innervation density does not adequately explain PHN pain and allodynia.
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