304PD Treatment approach and prognosis of pediatric and adolescent non-epithelial malignant ovarian tumors: A retrospective prognosis analysis

Abstract

Background Non-epithelial malignant ovarian tumors are rare in the pediatric and adolescent population. Because of the rarity of the disease, few studies with a large sample size are available, and survival and prognostic factors in this specific group of patients are poorly known. Methods This was a retrospective study of 170 girls (median age at presentation of 14 years) diagnosed with primary non-epithelial malignant ovarian tumors between 1990 and 2014 at the Sun Yat-sen Memorial Hospital and Cancer Center of Sun Yat-sen University. Symptoms, pathological data, treatments, and outcomes were obtained retrospectively from the medical records. Results Most (85.29%) tumors occurred in patients aged 10-18 years and most cases were FIGO stage I (70.0%). The predominant pathological type was germ cell tumors (87.06%). All patients underwent surgery, and 80 (47.06%) underwent conservative incomplete staging surgery (unilateral salpingo-oophorectomy or tumor excision). The 5-year progression-free survival (PFS) was 59.2%.The 5-year overall survival (OS) was 88.7%. Surgical hospital (HR = 0.388,95%CI=0.213-0.706, P = 0.002) was independently associated with PFS. Recurrence state (HR = 163.26,95%CI=1.321- 20181.875, P = 0.038) was independentlyassociatedwith OS. Conclusions Ovarian cancers in children and adolescents have features of good prognosis. Girls who received first operation in tertiary hospitals had better PFS. Patients who did not suffer recurrence had better OS. Legal entity responsible for the study Sun Yat-sen Memorial Hospital Funding N/A Disclosure All authors have declared no conflicts of interest.