Abstract
Objectives To determine whether concentrations of cytokines and C-reactive protein differentiate pregnant women with early-onset preeclampsia (EOPE) from late-onset preeclampsia (LOPE), and to identify whether there is a correlation between these concentrations and left ventricular hypertrophy (LVH). Methods A prospective cross-sectional study was performed with 85 pregnant women, classified into three groups: EOPE ( n = 30), LOPE (⩾ 34 weeks, n = 32) and NT (normotensive pregnant women, n = 23). Pregnant women underwent echocardiography examination by the time of the PE diagnosis or when NT pregnant women were paired with PE groups. Blood levels of C-reactive protein (CRP), tumor necrosis factor alpha (TNF- α ), IL-1 β , IL-6 and IL-10 were analyzed. Ventricular hypertrophy was considered when the ventricular mass index was ⩾45 g/m. The results were performed using nonparametric tests with a significance level set at 5%. Results TNF- α , IL-1 β and IL-6 were significantly higher in EOPE when compared with NT and LOPE. In LOPE, TNF- α and IL-6 were significantly higher when compared to the NT group. IL-10 were significantly lower whereas PCR values were significantly higher in preeclampsia women when compared with NT. Left ventricular hypertrophy was only associated with the increased concentration of IL-1 β in patients of EOPE. TNF- α and IL-6 were not associated with LVH. The low concentration of IL-10 was detected in the presence of LVH in both preeclampsia groups compared absence of LVH. The concentration of CRP did not differentiate between the groups, regardless the presence of LVH. Conclusions These results support the hypothesis that EOPE and LOPE have different pathophysiologies, since a more intense inflammation, associated with cardiac repercussions was detected in EOPE. Moreover, the association between high concentration of IL-1 β and cardiac hypertrophy suggests that this cytokine may play a relevant role in the development of this form of PE manifestation. Disclosures V.T. Borges: None. J.C. Peracoli: None. M. Romao: None. S. Zanati: None. J.R. Poiati: None. I.C. Weel: None. M.T. Peracoli: None.
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