Abstract
Circulating tumor cells (CTCs) are released from tumor tissue and provide tumor progression. The presence of stem and epithelial-mesenchymal transition (EMT) features in CTCs makes population extremely heterogenous and determines their invasiveness, adaptability to the microenvironment, and resistance to proapoptotic signals and chemotherapy. Integrins (ITGs), adhesion molecules, can determine organotropic metastasis when expressed on exosomes, as was shown in a study conducted by Hoshino A. et al.
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