Abstract
This study assessed the effects of acute exercise challenge testing (MAX-EX), as well as progressive exercise training, on Neuropeptide Y (NPY) and ALLO, two anti-stress and anti-nociceptive neurohormones, according to their relationship with pain sensitivity in a male and female population of civilians and Veterans with comorbid chronic pain and PTSD. The pilot sample (N=5) was 40% male (n=2), 60% female (n=3) with mean age of 35 years. Before exercise training, there were only small, non-significant positive correlations between MAX-EX test-induced increases in NPY or ALLO and indices of pain sensitivity (pain threshold and tolerance) assessed via a cold pressor test performed 30’ after the MAX-EX test (Δ NPY with pain threshold: =.36, p=.43; ΔALLO with pain tolerance: =-.37, p=.47). After exercise training, correlations between MAX-EX test-induced increases in NPY or ALLO and indices of pain sensitivity were high (ΔNPY with pain threshold: =.96, p
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