300. Creatine kinase: An independent risk factor for high blood pressure during pregnancy

Abstract

Hypertensive disorders in pregnancy not only pose a major burden during pregnancy, but are also associated with an increased risk for hypertension later in life. Plasma creatine kinase (CK) activity is identified in the general population as an independent risk factor for hypertension. We hypothesize that plasma CK activity is similarly associated with blood pressure during pregnancy. Women who participated in the Amsterdam Born Children and their Development-study were eligible for the current study. The associations between plasma CK activity and blood pressure measurements during pregnancy, and between plasma CK activity and hypertensive disorders in pregnancy (gestational hypertension, HELLP, preeclampsia and eclampsia) were evaluated using multiple linear- and logistic regression models, respectively. In 3.619 pregnant women, plasma CK activity was significantly associated with all blood pressure outcomes. This was most pronounced for the mean systolic blood pressure with a regression coefficient of 3.48 mmHg (CI 1.67 to 5.28, p Our data show that high plasma CK activity measured in early pregnancy is an independent risk factor for high blood pressure during pregnancy and is associated with severe gestational hypertension diagnosed before 34 weeks of gestation, while no significant association was found between CK and other hypertensive disorders in pregnancy.