Abstract
30 Years Old: O-GlcNAc Reaches the Age of Reason - Regulation of Cell Signaling and Metabolism by O-GlcNAcylation.
Highlights
This E-Book, which gathers Original Research papers, Method Articles, and Reviews published as part of a Research Topic in Frontiers in Endocrinology, is the opportunity to celebrate the thirtieth anniversary of the discovery of “O-GlcNAc.”
O-GlcNAcylation is generally presented as a glycosylation that occurs only in the cytosol, the nucleus, and to a lesser extent, in mitochondria, in contrast to “classical” and complex N and O-glycosylations that take place in the endoplasmic reticulum and the Golgi apparatus, and that modify transmembrane, secreted and organelle-confined proteins
Biology is often made of exceptions to rules, and O-GlcNAcylation of protein extracellular domains has been demonstrated in Drosophila [6]
Summary
This E-Book, which gathers Original Research papers, Method Articles, and Reviews published as part of a Research Topic in Frontiers in Endocrinology, is the opportunity to celebrate the thirtieth anniversary of the discovery of “O-GlcNAc.”. Protein O-GlcNAcylation levels in cells, resulting from the opposing actions of OGT and OGA, are tightly regulated.
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