Abstract
In previous studies we showed that oral administration of lipids with 67% MCT results in a hyperglycemic response. In the present prospective investigation, we studied the prophylactic effect of these lipids on the prevention of neonatal hypoglycemia. Fifty one low birth weight neonates were included in the investigation before the postnatal age of 10 hours. All but 4 were small-for-gestational age. They were randomly allocated to a control group(n=23) or to a supplemented group (n=28). There was no significant difference for gestational age, birthweight or ponderal index. Feeding with banked human milk was similar in both groups. The study group was supplemented lipids with 67% MCT (3g/24h). Hypoglycemia (i.e. plasmaglucose lower than 1.72 mM) occurred during the first four days in 2/28 neonates of the supplemented vs 8/23 neonates of the control group (X2 = 4.49; p<0.05). Hypoglycemia occurred espacially on Day2 after inclusion in the study in the control group 5/23 vs 1/28 in the supplemented group(p<0.01). The total number of hypoglycemic episodes was also higher in the control group(9/23) than in the supplemented group(2/28) :p<0.02. On the 2nd day of the study serum β-hydroxybutyrate was similar in the supplemented group (median:304μM =125-950) and in the control group(405μM=122-1080). These data suggest that lipids with 67% MCT can prevent hypoglycemia in the low birthThis result is observed without inducing a dangerous Ketosis.
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