Abstract
Through unknown mechanisms, fetal exposure to gestational diabetes mellitus (GDM) increases the risk for cardiometabolic disease development later in life. We hypothesize that fetal exposure to GDM alters cardiomyocyte metabolism and induces left ventricular (LV) dysfunction with age. To induce GDM, we fed female rats a high-fat (45% kcal) and sucrose diet prior to mating and throughout pregnancy. Lean control females received a low-fat (10% kcal) diet. Fetal rat ventricular cardiomyocytes (FRVC) were isolated from embryonic day (e) 20.5 offspring for U-13C glucose metabolic flux analysis.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
