30 EFFECT OF HIGH-DOSE VITAMIN D ON HYPERTENSION: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

Abstract

Background: Vitamin D deficiency has been linked with the risk of developing hypertension. Every 16 ng/mL decrease in vitamin D increase the risk of hypertension by 16%. Studies of standard vitamin D supplementation have not provided beneficial effect in lowering blood pressure in patients with hypertension. This study aims to determine the effect of high dose vitamin D supplementation in lowering blood pressure in hypertensive patient compared to placebo. Method: Systematic literatures search was conducted through online databases including PubMed and the Cochrane Library to find relevant randomized controlled trials (RCTs) from January 2010 to December 2021. Random-effect model was used to pool the weighted mean difference (WMD) of blood pressure across studies. Confidence Interval (CI) of 95% were reported. I2 test was used to assess the heterogeneity across studies. Meta-analysis was performed using RevMan 5.3. Result: Four RCTs involving 1100 participants were included. On pooled analysis, high dose vitamin D supplementation did not show significant reduction in systolic blood pressure compared to placebo (WMD, 0.37; 95% CI, - 1.34 to 2.09; p= 0.67). Similar finding was also found in the association of high dose vitamin D supplementation and diastolic blood pressure (WMD, 0.32;95% CI, - 0.80 to 1.45; p= 0.57). Conclusion: High dose vitamin D supplementation does not lower systolic and diastolic blood pressure in hypertensive patients