Abstract

External trigeminal nerve stimulation (TNS) is a noninvasive method of brain modulation that received FDA device clearance in 2019 for treatment of children aged 7 to 12 years with ADHD. Children randomized to active TNS exhibited significantly greater improvements in ADHD symptoms (p < .005) than sham and increased EEG power in the right frontal (F4) and frontal midline (Fz) brain regions. This presentation examines changes in resting-state functional connectivity to more fully characterize the neural mechanisms underlying TNS treatment–related improvements in ADHD.

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