3′UTR SNPs in the LPP gene associated with Immunoglobulin A nephropathy risk in the Chinese Han population

Abstract

The purpose of this study was to investigate the relationship between Lipoma preferred partner (LPP) gene polymorphisms and the risk of Immunoglobulin A nephropathy (IgAN) in the Chinese Han population. In this case-control study, we genotyped three single nucleotide polymorphisms (SNPs) of the LPP gene in 357 IgAN cases and 384 controls, using Agena Bioscience MassARRAY technology and assessed their association with IgAN using the χ2 test and genetic model analysis. The odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess risk and were adjusted for age and gender by logistic regression. In the allele model, there were significant associations between LPP rs1064607 (OR = 1.24; 95% CI = 1.01–1.53; p = 0.041), rs3796283 (OR = 1.32; 95% CI = 1.08–1.63; p = 0.008), and rs2378456 (OR = 1.29; 95% CI = 1.05–1.59; p = 0.016), as well as an increased risk of IgAN. In the dominant model, the “G/C-C/C” genotypes of rs1064607 (p = 0.023), the “G/A-G/G” genotypes of rs3796283 (p = 0.0013) and the “G/C-C/C” genotypes of rs2378456 (p = 0.00052) were risk factors for IgAN. The results of the stratified analysis showed that rs3796283 and rs2378456 were connected with susceptibility to IgAN in different subgroups. Our data may provide new evidence to research the etiology of IgAN.