3 The Medicinal Chemistry of 1,2,3-Triazines

Abstract

Publisher Summary This chapter focuses on the medicinal chemistry of 1,2,3-benzotriazines (2), benzotriazines (3) fused at the c bond to an azino- or azolo-ring (x), and the important series of hetero-fused 1,2,3-triazines (4). Some of the chemical and biological properties of diazonium compounds have been summarized in the chapter. The close parallel between the chemical properties of aryldiazonium compounds and 1,2,3-triazines fused to an aromatic carbocyclic or heterocyclic ring has been repeatedly stressed in this chapter. A medicinally desirable diazonium compound would test the skills of the most talented pharmaceutical formulator because of the inherent instability of this structural type: fused 1,2,3-triazines on the other hand are, in general, stable crystalline compounds readily amenable to manipulation yet lacking little in chemical versatility. Only a small proportion of the many structurally diverse 1,2,3-triazines that have been prepared over the years have been examined for biological activity.