3. Study on lipid profile among adults with HBV and HCV related chronic liver diseases in Bangladesh-report from a tertiary centre

Abstract

Background and Aims: Chronic Hepatitis B and C are the major causes of cirrhosis of Liver and Hepatocellular carcinoma in Bangladesh. Development of cirrhosis of liver result in derangement of metabolic functions. This study was conducted to find out the changes of lipid profile among adult with Chronic Viral Hepatitis B and C. Methods: This was cross sectional descriptive study in Medicine Inpatient Department of Rajshahi Medical College Hospital from June 2015 to july 2016. Total Number of Patients were 130. Among them 114 Chronic Hepatitis B and 16 patients chronic Hepatitis C. Age 18–65 years. Male 107, female 23. There were no comorbidities of these patients. Results: Among 130 Patients (116 Child's Pugh A & 14 Child's Pugh B). In HBV group Male 96, Female 18 and in HCV group Male 11, Female 05. Serum Total cholesterol, HDL, LDL and Serum Triglyceride were done in all patients in six monthly intervals. The results were reduction of Serum Total Cholesterol and HDL in 45 (39.47%) and increased Serum Triglyceride in 11 (09.65%) patients in HBV group. In HCV group increased Serum Total cholesterol and Serum Triglyceride in 07 (43.75%) and reduction of HDL in 03 (18.75%) patients. Conclusion: Developing countries like Bangladesh are likely to face an enormous burden of CLD and prevention and early diagnosis is essential to reduce economic loss and health system burden. Dyslipidemia is frequent in CLD & found with severity of the disease. Moreover, it may acts as a good predictor of CLD management. Till now, no needful studies are available in Bangladesh. Understanding the pattern of Dyslipidemia of hepatitis B & C related CLD in Bangladesh may enrich the clinician and may act as a baseline study for further research. The authors have none to declare.