Abstract
Introduction: Osteopontin (OPN), a ligand for alpha-v-beta-3 integrin and CD44 receptors, mediates metastatic behavior in a variety of cancers. However, the molecular mechanisms that regulate OPN gene expression in human colorectal cancer are unknown. Using SW480 human colon adenocarcinoma cells, we hypothesized that cis- and trans-transcriptional mechanisms determine OPN expression. Methods: SW480 human colon adenocarcinoma cells constitutively express OPN. Transient transfection and clonal deletion analysis of human OPN promoter (full-length 2.1 kb)-luciferase constructs identified cis-regulatory regions.
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