Abstract
The beneficial effects of oral L-serine (up to 500 mg/kg/day) and glycine (200 mg/kg/day) in 2 siblings, aged 7 and 5 years, with 3-phosphoglycerate dehydrogenase (3-PGDH) deficiency are reported from University Children’s Hospital, Utrecht, The Netherlands.
Highlights
The longterm outcome of 198 infants with malignant brain tumors treated postoperatively with prolonged chemotherapy is evaluated by a Pediatric Oncology Study Group
(200 mg/kg/day) in 2 siblings, aged 7 and 5 years, with 3-phosphoglycerate dehydrogenase (3-PGDH) deficiency are reported from University Children's Hospital, Utrecht, The Netherlands
Amino acid treatment resulted in complete control of seizures in 2 weeks, and the EEG abnormalities resolved in 6 months
Summary
The longterm outcome of 198 infants with malignant brain tumors treated postoperatively with prolonged chemotherapy (vincristine, cyclophosphamide, cisplatinum, and etoposide) is evaluated by a Pediatric Oncology Study Group. 3-PGDH DEFICIENCY, SEIZURES, AND MICROCEPHALY The beneficial effects of oral L-serine (up to 500 mg/kg/day) and glycine (200 mg/kg/day) in 2 siblings, aged 7 and 5 years, with 3-phosphoglycerate dehydrogenase (3-PGDH) deficiency are reported from University Children's Hospital, Utrecht, The Netherlands.
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