Abstract
AbstractThere has long been interest in obtaining optically pure molecules from racemic or non-chiral starting materials through environmentally friendly chemical transformations with high yields and enantioselectivities. Organocatalytic reactions possess the inherent advantages of non-toxicity and good efficiency and are insensitive to air and moisture. Dynamic kinetic resolution (DKR) represents one class of the most efficient strategies for the preparation of chiral molecules from racemic mixtures with up to 100% yields. Therefore, DKR reactions promoted by various organic catalysts are attractive based on their efficiencies, selectivities, and low toxicities. In this review, we introduce some representative examples of the reported DKR reactions catalyzed by typical organic catalysts, including chiral amines, Brønsted acids, N-heterocyclic carbenes, phosphines, guanidines, and isothioureas. The aim is to provide readers with a general overview of the scope and efficiency of organocatalytic DKR transformations and to inspire groundbreaking ideas for the development and applications of organocatalytic DKR reactions in future research.
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