Abstract
Abstract3‐Nitropropionic acid (NPA) elicited a dose‐dependent relaxation of precontracted rabbit aortic rings. Since the NPA effect was independent of the contractile agonist used, it did not appear to act by blocking a specific set of receptors. Aortic rings precontracted with KCl were less sensitive to relaxation by NPA suggesting that at least part of the mechanism of vasodilation is not related to an inhibition of calcium influx through the voltage‐dependent Ca+ + channel. The arterial relaxation induced by NPA is independent of endothelium and it is not mediated by muscarinic, β‐adrenergic, nor histaminergic (H1) receptors. On the other hand, methylene blue clearly inhibited the vasodilation induced by NPA suggesting that it is a consequence of guanylate cyclase stimulation. Finally, a mild but consistent decrease of both systolic and diastolic arterial blood pressure was observed after oral NPA administration during 4 weeks to renal hypertensive dogs. The data in the present study clearly demonstrate that NPA possesses vasodilator and antihypertensive properties. © 1993 Wiley‐Liss, Inc.
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