Abstract
The asymmetric unit of the title compound, C24H18N2O, comprises two crystallographically independent molecules (AandB), with slightly different conformations. In each molecule, there is an intramolecular C—H...O hydrogen bond forming anS(6) ring motif. The pyridazine rings of the pyrazolo[1,2-a]cinnoline units have screw-boat conformations. Their mean planes are inclined to the phenyl rings by 83.81 (8) and 74.19 (8)° in moleculeA, and 89.72 (8) and 71.07 (8)° in moleculeB. In the crystal, theAandBmolecules are linked by a pair of C—H...O hydrogen bonds, forming an A–B dimer with anR22(14) ring motif. These dimers are linked by further C—H...O hydrogen bonds, forming ribbons propagating along theb-axis direction. The ribbons are linked by a number of C—H...π interactions, forming a three-dimensional structure.
Highlights
The asymmetric unit of the title compound, C24H18N2O, comprises two crystallographically independent molecules (A and B), with slightly different conformations
The A and B molecules are linked by a pair of C—HÁ Á ÁO hydrogen bonds, forming an A–B dimer with an R22(14) ring motif
These dimers are linked by further C—HÁ Á ÁO hydrogen bonds, forming ribbons propagating along the b-axis direction
Summary
Pyrazole derivatives are reported to possess varied biological activities, such as antiinflammatory (Windholz 2003), analgesic (Windholz 2003), hypoglycemic, sedative (Burger & Iorio, 1979), hypnotic (Burger & Iorio, 1980), antifungal and antibacterial (Kalluraya & Ramesh, 2001). The asymmetric unit of the title compound, is composed of two crystallographically independent molecules (A and B), with slightly different conformations (Fig. 1). Intramolecular C—HÁ Á ÁO hydrogen bonds generate six-membered rings, producing S(6) ring motifs (Fig, Table 1). The dihedral angles between the mean plane of the central pyridazine ring (which has a screw-boat conformation in both molecules) and the two outer phenyl rings are 83.81 (8) and 74.19 (8) in molecule A, and 89.72 (8) and 71.07 (8) in molecule B. C24H18N2O 350.40 Triclinic, P1 293 9.9251 (4), 12.2293 (4), 15.1738 (5) 84.318 (2), 78.538 (2), 89.880 (2) 1795.86 (11) 4 Mo K 0.08 0.20 Â 0.15 Â 0.10
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