Abstract
The study aimed to find out the effect of Lactobacillus casei fermented milk as diabetic drug (Therapeutic). Mice were 3-4 month old, male and body weight ranged 20-30 g. This Research used Completely Randomized Design with factorial pattern, consisted of dose and duration of feeding. Treatments were divided into four treatment, P1 (no treatment), P2 (mice were induced with alloxan), P3 (mice were induced with alloxan and fed with fermented milk L. casei with 0.5 mL/mice) and P4 (mice were induced with alloxan and fed with Lactobacillus casei fermented milk 1 mL/mice). Provision of L. casei fermented milk provided at libitium and L. casei fermented milk given for 7 and 14 days. Blood were collected from Vena lateralis and dropped on the strip test Easy Touch GGHb. The results showed that not only dose administration of L. casei fermented milk had significantly decrease (P0.01) of glucose levels in mice, but also duration of treatment. It can be concluded that the administration of fermented milk L. casei can be used as a complement therapy for diabetic mice
Highlights
Diabetes adalah gangguan metabolisme kronis yang disebabkan karena tingginya kadar glukosa darah (Lin dan Sun, 2010)
The results showed that not only dose administration of L. casei fermented milk had significantly decrease (P
Effect of Lactobacillus gasseri BNR17 on blood glucose levels and body weight in a mouse model of type 2 diabetes
Summary
Prosedur Penelitian Penelitian ini merupakan penelitian eksperimental dengan menggunakan rancangan acak lengkap (RAL) pola faktorial yang terdiri dari 4 kelompok dengan 4 kali ulangan. Adapun keempat kelompok penelitian tersebut adalah: P1, tanpa perlakuan (control); P2, diinduksi dengan Aloksan; P3, diinduksi dengan aloksan dan yogurt dosis 0,5 ml/ekor; P4, diinduksi dengan aloksan dan yogurt dosis 1 ml/ ekor. Perlakuan hewan coba Mencit (Mus musculus) sebanyak 16 ekor yang berumur 3-4 bulan dengan berat badan 20-30 gram akan diadaptasi selama 1 minggu, pada tahap ini semua mencit diberi pakan standar. Pada akhir masa adaptasi masingmasing mencit ditimbang untuk mengetahui
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