Abstract
The reaction of electron-rich aminoheterocycles with 1,3-CCC -dielectrophiles, such as 3-formylchromones,acylpyruvates, and chalcone, provided diversely fused pyridines.Starting from 5-amino-1-(2,3- O-isopropylidene-β- D-ribofuranosyl)-1 H-pyrazole,nucleosides containing a pyrazolo[3,4- B]pyridinefragment were obtained, which can be considered as adenosine deaminase(ADA) inhibitors.
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