Abstract
Fully bio-based 3D porous scaffold based on cellulose nanofibers with potential use in cartilage tissue engineering was developed.
Highlights
Articular cartilage is an avascular, non-innervated tissue composed mostly of extracellular matrix (ECM) with a sparse population of chondrocytes distributed throughout the tissue and 70–85 wt% of water.[1]
Bio-based 3-dimensional porous scaffolds based on freeze-dried cellulose nanofibers (70–90 wt%) stabilized using a genipin crosslinked matrix of gelatin and chitosan were prepared
The lowered compression modulus of 10–60 kPa in phosphate buffered saline (PBS) at 37 C was considered favorable for chondrogenesis
Summary
Articular cartilage is an avascular, non-innervated tissue composed mostly of extracellular matrix (ECM) with a sparse population of chondrocytes distributed throughout the tissue and 70–85 wt% of water.[1] Due to its poor cell density and lack of blood vessels, cartilage has a very limited capacity to repair itself from defects caused by trauma or aging. In this respect, developing new tissue engineering approaches to repair cartilage defects and to restore cartilage function are of great interest.[2,3]. Their use is limited because of their lower mechanical properties when compared to synthetic polymers, especially load behaviour requirements necessary to allow proper cell proliferation.[10,11,12]
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