3-Dimensional (3D) cultures provide a renewable in vivo resource for the study of uterine fibroids in a mouse xenograft model: gross, histological and immunohistochemical analyses

Abstract

Uterine leiomyomas are benign tumors regulated by gonadal hormones and are composed of an abundance of disorganized extracellular matrix (ECM). Unfortunately, improved understanding has been hampered by limited, technically-difficult, or unreliable in vivo model systems. The goal of this study was to establish a reusable, well maintained source of transplanted material to validate a mouse xenograft model for the study of uterine leiomyomas.