Abstract
Most cancers exhibit the “Warburg effect”, consisting in increased glycolysis rates and lactate production, even in the presence of oxygen. Monocarboxylate transporters (MCTs) mediate lactate efflux through the plasma membrane. 3-bromopyruvate (3-BP) is an energetic inhibitor, with high anti-tumor efficiency either in rodent models or in humans. Being a pyruvate and lactate analogue, is likely to be transported by the same permeases, the monocarboxylate transporters (MCTs), which are upregulated in several cancer cells. In the present study, we aimed at determining the effect of 3-BP in three breast cancer cell lines (ZR-75–1, MCF-7 and SK-BR-3) and evaluate the putative role of MCTs on its cytotoxic effect.
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