Abstract
The crystal structure of the title compound, C27H45N3, has been determined as part of our investigation into the hydrophobic modification of aminoglycoside antibiotics. The isopropyl group showed disorder for the tertiary carbon (equal occupancies), with high thermal motion for the peripheral atoms of the isopropyl and azide groups also apparent in the structure. The axial disposition of the azide group is consistent with the clean inversion of stereochemistry at C-3 under Mitsunobu conditions.
Highlights
The crystal structure of the title compound, C27H45N3, has been determined as part of our investigation into the hydrophobic modification of aminoglycoside antibiotics
The axial disposition of the azide group is consistent with the clean inversion of stereochemistry at C-3 under Mitsunobu conditions
Supplementary data and figures for this paper are available from the IUCr electronic archives (Reference: TK2292)
Summary
Refinement R[F 2 > 2(F 2)] = 0.044 wR(F 2) = 0.125 S = 0.98 2428 reflections 280 parameters. V = 1250.52 (5) A 3 Z=2 Mo K radiation = 0.06 mmÀ1 T = 223 K 0.44 Â 0.39 Â 0.28 mm 2428 independent reflections 1883 reflections with I > 2(I) Rint = 0.027. 1 restraint H-atom parameters constrained Ámax = 0.20 e A À3 Ámin = À0.20 e A À3. The crystal structure of the title compound, C27H45N3, has been determined as part of our investigation into the hydrophobic modification of aminoglycoside antibiotics. The isopropyl group showed disorder for the tertiary carbon (equal occupancies), with high thermal motion for the peripheral atoms of the isopropyl and azide groups apparent in the structure. The axial disposition of the azide group is consistent with the clean inversion of stereochemistry at C-3 under Mitsunobu conditions
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