3.95 Decreased Immunoglobulin G is Associated With Pediatric-Onset OCD

Abstract

OCD is a common and often treatment-refractory neuropsychiatric disorder that is frequently with pediatric onset and persistence throughout adulthood. Immune-mediated processes have been implicated in at least some cases of pediatric OCD, and a better understanding of immune mechanisms is needed to identify biological targets to treat this disabling disorder early in development. We therefore aimed to broaden the scope of peripheral immune markers investigated in pediatric OCD by characterizing peripheral T-helper 17 cell-related cytokines and immunoglobulin profiles.