Abstract
3:54 PMAbstract No. 144 - PET/MRI of hepatic 90Y microsphere deposition determines individual tumor response
Highlights
Radioembolization of hepatic malignancies delivers higher radiation dose to tumors than surrounding liver parenchyma [1,2,3,4,5,6]
Dose volume histograms (DVHs) analysis of 90Y microsphere distribution following treatment may be an important predictor of response and could be used to guide future adaptive therapy trials
Between October 1, 2012 and April 17, 2014, patients undergoing radioembolization for any indication were recruited and consented on an IRB-approved protocol (NCT01744054) for positron emission tomography (PET)/magnetic resonance imaging (MRI) imaging on a Siemens Biograph mMR (Siemens Healthcare, Erlangen, Germany). 26 of these patients had imaging follow-up as defined as contrast-enhanced imaging at 3 months or later
Summary
Radioembolization of hepatic malignancies delivers higher radiation dose to tumors than surrounding liver parenchyma [1,2,3,4,5,6]. This is achieved by selective injection of a high-energy radiation source, 90Y [Yttrium-90, 0.93 MeV; tissue penetration mean 3.9 mm, maximum 11 mm], into the hepatic artery supplying the lobe or region of the tumor. The main complications of radioembolization are liver toxicity from radiation exposure and non-target embolization [8,9,10,11,12,13,14,15]. Response is generally heterogeneous between patients, even those with the same tumor types [16, 17]
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