Abstract
The 3,5-bis((E)-4-methoxybenzylidene)-1-(2-morpholinoethyl)piperidin-4-one (3) compound was synthesized by a two-step reaction with 92% yield. The chemical structure of compound 3 was confirmed by IR, NMR, and mass spectrometry. The title compound was screened for its anti-dengue activity against DENV2 NS2B-NS3 protease and showed 39.09% inhibitory activity at 200 µg/mL.
Highlights
Dengue is a major health problem in tropical countries and the subtropics and is caused by the dengue virus (DENV)
About 3.9 million humans in 128 countries are at risk of dengue virus infection
We reported synthetic curcumin from piperidone derivatives, where where some compounds showed potential anti-dengue activity through instudies silico studies the active some compounds showed potential anti-dengue activity through in silico on theon active site of site of
Summary
Dengue is a major health problem in tropical countries and the subtropics and is caused by the dengue virus (DENV). Balasubramanian et al (2018) reported some natural and synthetic curcumin derivatives for inhibiting dengue virus [10]. The anti-viral activity of curcumin containing piperidone was reported for the herpes virus (hsv1) and human immunodeficiency virus (HIV-1) [11]. We reported synthetic curcumin from piperidone derivatives, where where some compounds showed potential anti-dengue activity through instudies silico studies the active some compounds showed potential anti-dengue activity through in silico on theon active site of site of NS2B/NS3 protease [12,13,14]. We hope that this study screened against DENV2 NS2B-NS3 protease and a molecular docking study We hope that this could study contribute to the efforts in discovering potent potent anti-dengue agents.agents
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