Abstract
Three new naturally-occurring 3,4-dihydroquinoline-2-one derivatives: 8-Hydroxy-3,4-dihydro-1H-quinolin-2-one (1), 3,4-dihydro-1H-quinolin-2-one (2) and 8-methoxy-3,4-dihydro-1H-quinolin-2-one (3), together with linoleic acid, glycerol monolinoleate and phenyl acetic acid were isolated from the Streptomyces sp. LGE21, derived from Lemna gibba. Structures of the new alkaloids (1–3) were determined by extensive 1D and 2D NMR, and MS measurements. In vitro cytotoxic studies of 1–3 and linoleic acid, in comparison with the original extract were assayed against liver cancer HEPG2 cell line and the human cervix carcinoma cell line (KB-3-1). The antimicrobial activity of the strain extract and compounds 1–3 were achieved as well. The new metabolites exhibited weak cytotoxic activities against cancer cell lines and growth inhibitory activity against a panel of tested bacterial strains.
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